Cargando…
Signal Amplification in Highly Ordered Networks Is Driven by Geometry
Here, we hypothesize that, in biological systems such as cell surface receptors that relay external signals, clustering leads to substantial improvements in signaling efficiency. Representing cooperative signaling networks as planar graphs and applying Euler’s polyhedron formula, we can show that cl...
Autores principales: | Vanamee, Éva S., Lippner, Gábor, Faustman, Denise L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773832/ https://www.ncbi.nlm.nih.gov/pubmed/35053388 http://dx.doi.org/10.3390/cells11020272 |
Ejemplares similares
-
The benefits of clustering in TNF receptor superfamily signaling
por: Vanamee, Éva S., et al.
Publicado: (2023) -
On the TRAIL of Better Therapies: Understanding TNFRSF Structure-Function
por: Vanamee, Éva S., et al.
Publicado: (2020) -
Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling
por: Ban, Liqin, et al.
Publicado: (2015) -
Evolutionary games on isothermal graphs
por: Allen, Benjamin, et al.
Publicado: (2019) -
Microcapsule-Based Signal Amplification Method for Biomolecules
por: Yamaguchi, Masaki
Publicado: (2019)