TFEB Regulates ATP7B Expression to Promote Platinum Chemoresistance in Human Ovarian Cancer Cells

ATP7B is a hepato-specific Golgi-located ATPase, which plays a key role in the regulation of copper (Cu) homeostasis and signaling. In response to elevated Cu levels, ATP7B traffics from the Golgi to endo-lysosomal structures, where it sequesters excess copper and further promotes its excretion to t...

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Detalles Bibliográficos
Autores principales: Petruzzelli, Raffaella, Mariniello, Marta, De Cegli, Rossella, Catalano, Federico, Guida, Floriana, Di Schiavi, Elia, Polishchuk, Roman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774088/
https://www.ncbi.nlm.nih.gov/pubmed/35053335
http://dx.doi.org/10.3390/cells11020219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774088/
https://www.ncbi.nlm.nih.gov/pubmed/35053335
http://dx.doi.org/10.3390/cells11020219

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