Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics

Substrate binding to the cytochrome P450 OleP is coupled to a large open-to-closed transition that remodels the active site, minimizing its exposure to the external solvent. When the aglycone substrate binds, a small empty cavity is formed between the I and G helices, the BC loop, and the substrate...

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Detalles Bibliográficos
Autores principales: Montemiglio, Linda Celeste, Gugole, Elena, Freda, Ida, Exertier, Cécile, D’Auria, Lucia, Chen, Cheng Giuseppe, Nardi, Alessandro Nicola, Cerutti, Gabriele, Parisi, Giacomo, D’Abramo, Marco, Savino, Carmelinda, Vallone, Beatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774231/
https://www.ncbi.nlm.nih.gov/pubmed/35053203
http://dx.doi.org/10.3390/biom12010055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774231/
https://www.ncbi.nlm.nih.gov/pubmed/35053203
http://dx.doi.org/10.3390/biom12010055

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