In Silico, In Vitro and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway

Tanshinone IIA (TIIA) and cryptotanshinone (CRY) from Salvia miltiorrhiza Bunge were investigated for their inhibitory activity against the cyclooxygenase-2 (COX-2)/microsomal prostaglandin E synthase-1 (mPGES-1)/endothelial prostaglandin 3 (EP3) pathway using in silico, in vitro, in vivo, and ex vi...

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Detalles Bibliográficos
Autores principales: Saviano, Anella, De Vita, Simona, Chini, Maria Giovanna, Marigliano, Noemi, Lauro, Gianluigi, Casillo, Gian Marco, Raucci, Federica, Iorizzi, Maria, Hofstetter, Robert Klaus, Fischer, Katrin, Koeberle, Andreas, Werz, Oliver, Maione, Francesco, Bifulco, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774285/
https://www.ncbi.nlm.nih.gov/pubmed/35053247
http://dx.doi.org/10.3390/biom12010099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774285/
https://www.ncbi.nlm.nih.gov/pubmed/35053247
http://dx.doi.org/10.3390/biom12010099

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