Cargando…

In Silico, In Vitro and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway

Tanshinone IIA (TIIA) and cryptotanshinone (CRY) from Salvia miltiorrhiza Bunge were investigated for their inhibitory activity against the cyclooxygenase-2 (COX-2)/microsomal prostaglandin E synthase-1 (mPGES-1)/endothelial prostaglandin 3 (EP3) pathway using in silico, in vitro, in vivo, and ex vi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saviano, Anella, De Vita, Simona, Chini, Maria Giovanna, Marigliano, Noemi, Lauro, Gianluigi, Casillo, Gian Marco, Raucci, Federica, Iorizzi, Maria, Hofstetter, Robert Klaus, Fischer, Katrin, Koeberle, Andreas, Werz, Oliver, Maione, Francesco, Bifulco, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774285/ https://www.ncbi.nlm.nih.gov/pubmed/35053247 http://dx.doi.org/10.3390/biom12010099

Ejemplares similares

Metabolism of Tanshinone IIA, Cryptotanshinone and Tanshinone I from Radix Salvia Miltiorrhiza in Zebrafish
por: Wei, Yingjie, et al.
Publicado: (2012)

Present Status and Future Trends of Natural-Derived Compounds Targeting T Helper (Th) 17 and Microsomal Prostaglandin E Synthase-1 (mPGES-1) as Alternative Therapies for Autoimmune and Inflammatory-Based Diseases
por: Saviano, Anella, et al.
Publicado: (2020)

Simultaneous purification of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA from Salvia miltiorrhiza and their anti-inflammatory activities investigation
por: Gao, Hongwei, et al.
Publicado: (2018)

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol
por: Noha, Stefan M., et al.
Publicado: (2015)

Tanshinone IIA and Cryptotanshinone Counteract Inflammation by Regulating Gene and miRNA Expression in Human SGBS Adipocytes
por: Carpi, Sara, et al.
Publicado: (2023)

Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E(2) and Leukotriene Biosynthesis Inhibitors
por: Potenza, Marianna, et al.
Publicado: (2022)

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor
por: Di Micco, Simone, et al.
Publicado: (2022)

Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition
por: Di Micco, Simone, et al.
Publicado: (2021)

Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza
por: Jiang, Zhouqian, et al.
Publicado: (2019)

The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza
por: Ma, Xiao-Hui, et al.
Publicado: (2015)

mPGES-1 and prostaglandin E(2): vital role in inflammation, hypoxic response, and survival
por: Siljehav, Veronica, et al.
Publicado: (2012)

Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza
por: Gao, Wei, et al.
Publicado: (2014)

Targeting mPGES-1 as a New Strategy against Neuroblastoma
por: Comunanza, Valentina
Publicado: (2018)

Analgesic effects of a highly selective mPGES-1 inhibitor
por: Stewart, Madeline J., et al.
Publicado: (2023)

Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions
por: Adams, James David, et al.
Publicado: (2006)

Antihypertension Induced by Tanshinone IIA Isolated from the Roots of Salvia miltiorrhiza
por: Chan, Paul, et al.
Publicado: (2011)

Spatiotemporal and Transcriptional Characterization on Tanshinone Initial Synthesis in Salvia miltiorrhiza Roots
por: Lin, Caicai, et al.
Publicado: (2022)

Mycobacterium tuberculosis-Induced Upregulation of the COX-2/mPGES-1 Pathway in Human Macrophages Is Abrogated by Sulfasalazine
por: Wang, Wenfei, et al.
Publicado: (2022)

Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
por: Takeda, H, et al.
Publicado: (2004)

Transcriptional regulation of the mPGES-1 gene in primary cultured articular chondrocytes
por: Bausero, P, et al.
Publicado: (2004)

mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
por: McCann, Matthew R, et al.
Publicado: (2011)

Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis
por: Kirkby, Nicholas S, et al.
Publicado: (2019)

Inhibition of bone resorption by Tanshinone VI isolated from Salvia miltiorrhiza Bunge
por: Nicolin, V., et al.
Publicado: (2010)

The 2-oxoglutarate-dependent dioxygenase superfamily participates in tanshinone production in Salvia miltiorrhiza
por: Xu, Zhichao, et al.
Publicado: (2017)

Enhancement of tanshinone production in Salvia miltiorrhiza hairy root cultures by metabolic engineering
por: Wei, Tao, et al.
Publicado: (2019)

Transcriptomic analysis reveals potential genes involved in tanshinone biosynthesis in Salvia miltiorrhiza
por: Chang, Yujie, et al.
Publicado: (2019)

Comparative transcriptome analyses of different Salvia miltiorrhiza varieties during the accumulation of tanshinones
por: Zhou, Jingwen, et al.
Publicado: (2021)

An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)
por: Naz, Irum, et al.
Publicado: (2020)

Characteristics of Salvia miltiorrhiza methylome and the regulatory mechanism of DNA methylation in tanshinone biosynthesis
por: Li, Jiang, et al.
Publicado: (2023)

New Insights Into the Antibacterial Mechanism of Cryptotanshinone, a Representative Diterpenoid Quinone From Salvia miltiorrhiza Bunge
por: Chen, Bo-Chen, et al.
Publicado: (2021)

Pulmonary and Cardiorenal Cyclooxygenase-1 (COX-1), -2 (COX-2), and Microsomal Prostaglandin E Synthase-1 (mPGES-1) and -2 (mPGES-2) Expression in a Hypertension Model
por: Radi, Zaher A., et al.
Publicado: (2007)

Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E(2) Synthase-1 (mPGES-1)
por: Waltenberger, Birgit, et al.
Publicado: (2011)

Correction: mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
por: McCann, Matthew R, et al.
Publicado: (2011)

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice
por: Brenneis, Christian, et al.
Publicado: (2008)

Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent
por: Kothavade, Pankaj S., et al.
Publicado: (2013)

Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones
por: Zhai, Xifeng, et al.
Publicado: (2017)

Transcriptome Analysis of Medicinal Plant Salvia miltiorrhiza and Identification of Genes Related to Tanshinone Biosynthesis
por: Yang, Lei, et al.
Publicado: (2013)

Transcription Factor SmWRKY1 Positively Promotes the Biosynthesis of Tanshinones in Salvia miltiorrhiza
por: Cao, Wenzhi, et al.
Publicado: (2018)

Bioavailability and pharmacokinetic comparison of tanshinones between two formulations of Salvia miltiorrhiza in healthy volunteers
por: Xing, Lu, et al.
Publicado: (2017)

Proteomic analysis reveals novel insights into tanshinones biosynthesis in Salvia miltiorrhiza hairy roots
por: Contreras, Angela, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jsnj49c04on046arbe7p369l07