Role of Mitochondrial Cytochrome P450 2E1 in Healthy and Diseased Liver

Cytochrome P450 2E1 (CYP2E1) is pivotal in hepatotoxicity induced by alcohol abuse and different xenobiotics. In this setting, CYP2E1 generates reactive metabolites inducing oxidative stress, mitochondrial dysfunction and cell death. In addition, this enzyme appears to play a role in the progression...

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Detalles Bibliográficos
Autores principales: Massart, Julie, Begriche, Karima, Hartman, Jessica H., Fromenty, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774478/
https://www.ncbi.nlm.nih.gov/pubmed/35053404
http://dx.doi.org/10.3390/cells11020288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774478/
https://www.ncbi.nlm.nih.gov/pubmed/35053404
http://dx.doi.org/10.3390/cells11020288

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