A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data

Polygenic risk scores are a popular means to predict the disease risk or disease susceptibility of an individual based on its genotype information. When adding other important epidemiological covariates such as age or sex, we speak of an integrated risk model. Methodological advances for fitting mor...

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Detalles Bibliográficos
Autores principales: Hahn, Georg, Prokopenko, Dmitry, Lutz, Sharon M., Mullin, Kristina, Tanzi, Rudolph E., Cho, Michael H., Silverman, Edwin K., Lange, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775060/
https://www.ncbi.nlm.nih.gov/pubmed/35052450
http://dx.doi.org/10.3390/genes13010112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775060/
https://www.ncbi.nlm.nih.gov/pubmed/35052450
http://dx.doi.org/10.3390/genes13010112

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