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Influenza-induced Tpl2 expression within alveolar epithelial cells is dispensable for host viral control and anti-viral immunity

Tumor progression locus 2 (Tpl2) is a serine/threonine kinase that regulates the expression of inflammatory mediators in response to Toll-like receptors (TLR) and cytokine receptors. Global ablation of Tpl2 leads to severe disease in response to influenza A virus (IAV) infection, characterized by re...

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Detalles Bibliográficos
Autores principales: Wyatt, Kara D., Sarr, Demba, Sakamoto, Kaori, Watford, Wendy T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775564/
https://www.ncbi.nlm.nih.gov/pubmed/35051238
http://dx.doi.org/10.1371/journal.pone.0262832