Cargando…

Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice

The damaging effects of ionizing radiation (IR) on bone mass are well-documented in mice and humans and are most likely due to increased osteoclast number and function. However, the mechanisms leading to inappropriate increases in osteoclastic bone resorption are only partially understood. Here, we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Richardson, Kimberly K., Ling, Wen, Krager, Kimberly, Fu, Qiang, Byrum, Stephanie D., Pathak, Rupak, Aykin-Burns, Nukhet, Kim, Ha-Neui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775597/ https://www.ncbi.nlm.nih.gov/pubmed/35054859 http://dx.doi.org/10.3390/ijms23020675

Ejemplares similares

Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
por: Kim, Ha-Neui, et al.
Publicado: (2021)

Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
por: Ling, Wen, et al.
Publicado: (2021)

Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
por: Wang, Xiaoyan, et al.
Publicado: (2022)

Modulation of Radiation Response by the Tetrahydrobiopterin Pathway
por: Pathak, Rupak, et al.
Publicado: (2015)

Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors
por: Kim, Ha-Neui, et al.
Publicado: (2020)

Peroxynitrite induced mitochondrial biogenesis following MnSOD knockdown in normal rat kidney (NRK) cells()
por: Marine, Akira, et al.
Publicado: (2014)

Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
por: Nukala, Ujwani, et al.
Publicado: (2018)

Liver Metabolomics Reveals Increased Oxidative Stress and Fibrogenic Potential in Gfrp Transgenic Mice in Response to Ionizing Radiation
por: Cheema, Amrita K, et al.
Publicado: (2014)

PCB11 Metabolite, 3,3’-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3: Examining the Contribution of MnSOD
por: Alam, Sinthia, et al.
Publicado: (2018)

The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury
por: LoBianco, Francesca V., et al.
Publicado: (2020)

Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
por: Shrum, Stephen A., et al.
Publicado: (2023)

Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity
por: Krager, Kimberly J., et al.
Publicado: (2015)

Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes
por: Banerjee, Sudip, et al.
Publicado: (2017)

Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
por: Das, Bhaba K, et al.
Publicado: (2022)

Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
por: LoBianco, Francesca V., et al.
Publicado: (2022)

Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose
por: Sadhukhan, Ratan, et al.
Publicado: (2020)

Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
por: Sridharan, Vijayalakshmi, et al.
Publicado: (2021)

An inhibitor of K(+ )channels modulates human endometrial tumor-initiating cells
por: Schickling, Brandon M, et al.
Publicado: (2011)

Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in mice
por: Kim, Ha‐Neui, et al.
Publicado: (2019)

BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway
por: SCHICKLING, BRANDON M., et al.
Publicado: (2015)

ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens
por: Marques-Carvalho, Adriana, et al.
Publicado: (2023)

Mitochondrial adaptation in human mesenchymal stem cells following ionizing radiation
por: Patten, David A., et al.
Publicado: (2019)

TLR4—A Pertinent Player in Radiation-Induced Heart Disease?
por: Gawali, Basveshwar, et al.
Publicado: (2023)

Fundamentals of ionizing radiation dosimetry
por: Andreo, Pedro, et al.
Publicado: (2017)

Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis
por: Park, Seong-Hoon, et al.
Publicado: (2011)

Ionizing radiation and aging: rejuvenating an old idea
por: Richardson, Richard B.
Publicado: (2009)

α-Tocopheryl Succinate Inhibits Osteoclast Formation by Suppressing Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL) Expression and Bone Resorption
por: Kim, Ha-Neui, et al.
Publicado: (2012)

C/EBPδ Deficiency Sensitizes Mice to Ionizing Radiation-Induced Hematopoietic and Intestinal Injury
por: Pawar, Snehalata A., et al.
Publicado: (2014)

Ionizing Radiation and Chronic Lymphocytic Leukemia
por: Richardson, David B., et al.
Publicado: (2005)

Lipopolysaccharide sensitized male and female juvenile brains to ionizing radiation
por: Kalm, M, et al.
Publicado: (2013)

Ionizing radiation
por: Reeve, Tamar
Publicado: (2018)

Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation
por: Miousse, Isabelle R., et al.
Publicado: (2017)

Burden of Ionizing Radiation in the Diagnosis and Management of Necrotizing Pancreatitis
por: Thiruvengadam, Nikhil R., et al.
Publicado: (2021)

Radiation Biophysics: (Ionizing Radiations)
por: Kudryashov, Yurii B
Publicado: (2008)

The dosimetry of ionizing radiation
por: Attix, Frank H, et al.
Publicado: (1987)

The dosimetry of ionizing radiation
por: Attix, Frank H, et al.
Publicado: (1985)

The dosimetry of ionizing radiation
por: Collective
Publicado: (1990)

STUDIES ON THE MECHANISM OF ACTION OF IONIZING RADIATIONS : VI. THE OXIDATION OF THIOLS BY IONIZING RADIATIONS
por: Barron, E. S. Guzman, et al.
Publicado: (1950)

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss
por: Dobson, Philip F., et al.
Publicado: (2020)

Ionization loss in BGO
por: Bakken, J A, et al.
Publicado: (1987)

Cannot write session to /tmp/vufind_sessions/sess_g9apgpfl8sjobjd9bm0tred4aj