Novel Mechanism by a Bis-Pyridinium Fullerene Derivative to Induce Apoptosis by Enhancing the MEK-ERK Pathway in a Reactive Oxygen Species-Independent Manner in BCR-ABL-Positive Chronic Myeloid Leukemia-Derived K562 Cells

In the treatment of breakpoint cluster region-Abelson (BCR-ABL)-positive chronic myeloid leukemia (CML) using BCR-ABL inhibitors, the appearance of a gatekeeper mutation (T315I) in BCR-ABL is a serious issue. Therefore, the development of novel drugs that overcome acquired resistance to BCR-ABL inhi...

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Detalles Bibliográficos
Autores principales: Sumi, Kazuya, Tago, Kenji, Nakazawa, Yosuke, Takahashi, Kyoko, Ohe, Tomoyuki, Mashino, Tadahiko, Funakoshi-Tago, Megumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775703/
https://www.ncbi.nlm.nih.gov/pubmed/35054935
http://dx.doi.org/10.3390/ijms23020749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775703/
https://www.ncbi.nlm.nih.gov/pubmed/35054935
http://dx.doi.org/10.3390/ijms23020749

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