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Novel Mechanism by a Bis-Pyridinium Fullerene Derivative to Induce Apoptosis by Enhancing the MEK-ERK Pathway in a Reactive Oxygen Species-Independent Manner in BCR-ABL-Positive Chronic Myeloid Leukemia-Derived K562 Cells

In the treatment of breakpoint cluster region-Abelson (BCR-ABL)-positive chronic myeloid leukemia (CML) using BCR-ABL inhibitors, the appearance of a gatekeeper mutation (T315I) in BCR-ABL is a serious issue. Therefore, the development of novel drugs that overcome acquired resistance to BCR-ABL inhi...

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Detalles Bibliográficos
Autores principales:	Sumi, Kazuya, Tago, Kenji, Nakazawa, Yosuke, Takahashi, Kyoko, Ohe, Tomoyuki, Mashino, Tadahiko, Funakoshi-Tago, Megumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775703/ https://www.ncbi.nlm.nih.gov/pubmed/35054935 http://dx.doi.org/10.3390/ijms23020749

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