Intracellular HINT1-Assisted Hydrolysis of Nucleoside 5′-O-Selenophosphate Leads to the Release of Hydrogen Selenide That Exhibits Toxic Effects in Human Cervical Cancer Cells

In this study, we present a new selenium derivative, 2′-deoxyguanosine-5′-O-selenophosphate (dGMPSe), synthesized by the oxathiaphospholane method and adapted here for the synthesis of nucleoside selenophosphates. Using biochemical assays (HPLC- and fluorescence-based), we investigated the enzymatic...

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Detalles Bibliográficos
Autores principales: Krakowiak, Agnieszka, Czernek, Liliana, Pichlak, Marta, Kaczmarek, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775712/
https://www.ncbi.nlm.nih.gov/pubmed/35054788
http://dx.doi.org/10.3390/ijms23020607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775712/
https://www.ncbi.nlm.nih.gov/pubmed/35054788
http://dx.doi.org/10.3390/ijms23020607

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