Analysis of Integrin α(IIb) Subunit Dynamics Reveals Long-Range Effects of Missense Mutations on Calf Domains

Integrin α(IIb)β(3), a glycoprotein complex expressed at the platelet surface, is involved in platelet aggregation and contributes to primary haemostasis. Several integrin α(IIb)β(3) polymorphisms prevent the aggregation that causes haemorrhagic syndromes, such as Glanzmann thrombasthenia (GT). Acce...

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Detalles Bibliográficos
Autores principales: Anies, Sali, Jallu, Vincent, Diharce, Julien, Narwani, Tarun J., de Brevern, Alexandre G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776176/
https://www.ncbi.nlm.nih.gov/pubmed/35055046
http://dx.doi.org/10.3390/ijms23020858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776176/
https://www.ncbi.nlm.nih.gov/pubmed/35055046
http://dx.doi.org/10.3390/ijms23020858

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