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Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

Mechanosensory transduction (MT), the conversion of mechanical stimuli into electrical signals, underpins hearing and balance and is carried out within hair cells in the inner ear. Hair cells harbor actin-filled stereocilia, arranged in rows of descending heights, where the tips of stereocilia are c...

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Detalles Bibliográficos
Autores principales: Elferich, Johannes, Clark, Sarah, Ge, Jingpeng, Goehring, April, Matsui, Aya, Gouaux, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776254/
https://www.ncbi.nlm.nih.gov/pubmed/34964715
http://dx.doi.org/10.7554/eLife.74512