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Overexpression of Parkin in clear cell renal cell carcinoma decreases tumor aggressiveness by regulating CKS2 levels

Low expression levels of the E3 ubiquitin-protein ligase Parkin (PARK2) are exhibited in several cancer entities, including clear cell renal cell carcinoma (ccRCC), and are associated with poor prognosis; however, PARK2 can also function as a tumor suppressor gene. The aim of the present study was t...

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Detalles Bibliográficos
Autores principales: Esser, Laura Kristin, Branchi, Vittorio, Shakeri, Farhad, Simon, Adrian Georg, Stephan, Carsten, Kristiansen, Glen, Buness, Andreas, Schorle, Hubert, Toma, Marieta Ioana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776329/
https://www.ncbi.nlm.nih.gov/pubmed/35059737
http://dx.doi.org/10.3892/ijo.2022.5310