Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment

Chronic inflammation is an underlying cause in a number of diseases. Cyclin-dependent kinase 8 (CDK8) has been implicated as an inflammatory mediator, indicating its potential as an anti-inflammatory target. Herein, we performed structure-based virtual screening (SBVS) to identify novel CDK8 inhibit...

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Detalles Bibliográficos
Autores principales: Lin, Tony Eight, Yang, Chia-Ron, Chou, Ching-Hsuan, Hsu, Jui-Yi, Chao, Min-Wu, Sung, Tzu-Ying, Hsieh, Jui-Hua, Huang, Wei-Jan, Hsu, Kai-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776612/
https://www.ncbi.nlm.nih.gov/pubmed/34953394
http://dx.doi.org/10.1016/j.biopha.2021.112459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776612/
https://www.ncbi.nlm.nih.gov/pubmed/34953394
http://dx.doi.org/10.1016/j.biopha.2021.112459

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