Inhibition of MCL1 induces apoptosis in anaplastic large cell lymphoma and in primary effusion lymphoma

Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignancies and contributes to tumorigenesis by inhibiting the apoptotic machinery of the cells. Antagonizing BH3 mimetics provide an option for medication, with venetoclax as the first drug applied for chronic lymph...

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Detalles Bibliográficos
Autores principales: Quentmeier, Hilmar, Geffers, Robert, Hauer, Vivien, Nagel, Stefan, Pommerenke, Claudia, Uphoff, Cord C., Zaborski, Margarete, Drexler, Hans G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776734/
https://www.ncbi.nlm.nih.gov/pubmed/35058488
http://dx.doi.org/10.1038/s41598-022-04916-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776734/
https://www.ncbi.nlm.nih.gov/pubmed/35058488
http://dx.doi.org/10.1038/s41598-022-04916-6

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