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GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation
Bone metastases occur in patients with advanced-stage prostate cancer (PCa). The cell-cell interaction between PCa and the bone microenvironment forms a vicious cycle that modulates the bone microenvironment, increases bone deformities, and drives tumor growth in the bone. However, the molecular mec...
Autores principales: | Siddiqui, Jawed Akhtar, Seshacharyulu, Parthasarathy, Muniyan, Sakthivel, Pothuraju, Ramesh, Khan, Parvez, Vengoji, Raghupathy, Chaudhary, Sanjib, Maurya, Shailendra Kumar, Lele, Subodh Mukund, Jain, Maneesh, Datta, Kaustubh, Nasser, Mohd Wasim, Batra, Surinder Kumar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776828/ https://www.ncbi.nlm.nih.gov/pubmed/35058441 http://dx.doi.org/10.1038/s41413-021-00178-6 |
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