cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence

As a sensor of cytosolic DNA, the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established, yet how its functions in different biological conditions remain to be elucidated. Here, we identify cGAS as an essential regulator in inhibiting mitotic DNA double-strand break (DS...

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Detalles Bibliográficos
Autores principales: Li, Xiaocui, Li, Xiaojuan, Xie, Chen, Cai, Sihui, Li, Mengqiu, Jin, Heping, Wu, Shu, Cui, Jun, Liu, Haiying, Zhao, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776970/
https://www.ncbi.nlm.nih.gov/pubmed/34676498
http://dx.doi.org/10.1007/s13238-021-00879-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776970/
https://www.ncbi.nlm.nih.gov/pubmed/34676498
http://dx.doi.org/10.1007/s13238-021-00879-y

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