Cargando…

Genetic Blockade of NAAA Cell-specifically Regulates Fatty Acid Ethanolamides (FAEs) Metabolism and Inflammatory Responses

N-Acylethanolamine acid amidase (NAAA) is a lysosomal enzyme responsible for the hydrolysis of fatty acid ethanolamides (FAEs). However, the role of NAAA in FAEs metabolism and regulation of pain and inflammation remains mostly unknown. Here, we generated NAAA-deficient (NAAA(-/-)) mice using CRISPR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Xiaohua, Li, Yitian, Xu, Sennan, Zhou, Pan, Yang, Longhe, Xu, Yaping, Qiu, Yan, Yang, Yungang, Li, Yuhang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777083/ https://www.ncbi.nlm.nih.gov/pubmed/35069223 http://dx.doi.org/10.3389/fphar.2021.817603

Ejemplares similares

Natural Potent NAAA Inhibitor Atractylodin Counteracts LPS-Induced Microglial Activation
por: Yang, Longhe, et al.
Publicado: (2020)

Design and Synthesis of Potent N-Acylethanolamine-hydrolyzing Acid Amidase (NAAA) Inhibitor as Anti-Inflammatory Compounds
por: Li, Yuhang, et al.
Publicado: (2012)

A New Use for an Old Drug: Carmofur Attenuates Lipopolysaccharide (LPS)-Induced Acute Lung Injury via Inhibition of FAAH and NAAA Activities
por: Wu, Kangni, et al.
Publicado: (2019)

Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA Pathway
por: Jin, Wenhui, et al.
Publicado: (2020)

Molecular Targets of Fatty Acid Ethanolamides in Asthma
por: Kytikova, Oxana, et al.
Publicado: (2019)

GPR119 and GPR55 as Receptors for Fatty Acid Ethanolamides, Oleoylethanolamide and Palmitoylethanolamide
por: Im, Dong-Soon
Publicado: (2021)

FaesAP3_1 Regulates the FaesELF3 Gene Involved in Filament-Length Determination of Long-Homostyle Fagopyrum esculentum
por: Ma, Zhiyuan, et al.
Publicado: (2022)

N-Palmitoylethanolamine Maintains Local Lipid Homeostasis to Relieve Sleep Deprivation–Induced Dry Eye Syndrome
por: Chen, Qi, et al.
Publicado: (2020)

Corylin accelerated wound healing through SIRT1 and PI3K/AKT signaling: a candidate remedy for chronic non-healing wounds
por: Xiu, Yanghui, et al.
Publicado: (2023)

Fatty acid amide hydrolase and 9-lipoxygenase modulate cotton seedling growth by ethanolamide oxylipin levels
por: Arias-Gaguancela, Omar, et al.
Publicado: (2022)

FeAture Explorer (FAE): A tool for developing and comparing radiomics models
por: Song, Yang, et al.
Publicado: (2020)

Insights Into the Prognostic Value and Immunological Role of NAAA in Pan-Cancer
por: Huang, Da, et al.
Publicado: (2022)

Characterization of FAE1 in the zero erucic acid germplasm of Brassica rapa L.
por: Yan, Guixin, et al.
Publicado: (2015)

NAAA-regulated lipid signaling governs the transition from acute to chronic pain
por: Fotio, Yannick, et al.
Publicado: (2021)

Caffeic acid ethanolamide prevents cardiac dysfunction through sirtuin dependent cardiac bioenergetics preservation
por: Lee, Shih-Yi, et al.
Publicado: (2015)

Sex-Specific Whole-Transcriptome Analysis in the Cerebral Cortex of FAE Offspring
por: Mishra, Nitish K., et al.
Publicado: (2023)

Synergic Therapeutic Potential of PEA-Um Treatment and NAAA Enzyme Silencing In the Management of Neuroinflammation
por: Casili, Giovanna, et al.
Publicado: (2020)

Evolutionary Pattern of the FAE1 Gene in Brassicaceae and Its Correlation with the Erucic Acid Trait
por: Sun, Xiaoqin, et al.
Publicado: (2013)

New role for the anandamide metabolite prostaglandin F(2α) ethanolamide: Rolling preadipocyte proliferation
por: Boubertakh, Besma, et al.
Publicado: (2023)

Four Undescribed Pyranones from the Scutellaria formosana-Derived Endophytic Fungi Ascomycota sp. FAE17
por: Yang, Jianni, et al.
Publicado: (2023)

Interleukin-6 Receptor Blockade can Increase the Risk of Nonalcoholic Fatty Liver Disease: Indications From Mendelian Randomization
por: Li, Shuxuan, et al.
Publicado: (2022)

Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease
por: Borkowski, Kamil, et al.
Publicado: (2021)

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy
por: Jiang, Mengjie, et al.
Publicado: (2019)

Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma
por: Liu, Songlin, et al.
Publicado: (2019)

Micronized Palmitoylethanolamide Ameliorates Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis via Inhibiting Inflammation and Restoring Autophagy
por: Hu, Jiaji, et al.
Publicado: (2021)

Concerted increases of FAE1 expression level and substrate availability improve and singularize the production of very‐long‐chain fatty acids in Arabidopsis seeds
por: Ma, Shijie, et al.
Publicado: (2021)

CRISPR/Cas9-Mediated Gene Editing of BnFAD2 and BnFAE1 Modifies Fatty Acid Profiles in Brassica napus
por: Shi, Jianghua, et al.
Publicado: (2022)

Nuciferine Ameliorates Inflammatory Responses by Inhibiting the TLR4-Mediated Pathway in Lipopolysaccharide-Induced Acute Lung Injury
por: Wu, Haichong, et al.
Publicado: (2017)

Liposomal N-acylethanolamine-hydrolyzing acid amidase (NAAA) inhibitor F96 as a new therapy for colitis
por: Xiu, Yangyan, et al.
Publicado: (2020)

Inhibition of triple negative breast cancer-associated inflammation and progression by N- acylethanolamine acid amide hydrolase (NAAA)
por: Benchama, Othman, et al.
Publicado: (2022)

Blockade of Autophagy Prevents the Development and Progression of Peritoneal Fibrosis
por: Shi, Yingfeng, et al.
Publicado: (2021)

Development and validation of functional CAPS markers for the FAE genes in Brassica juncea and their use in marker-assisted selection
por: Saini, Navinder, et al.
Publicado: (2016)

Deletion of FaeG alleviated Enterotoxigenic Escherichia coli F4ac-induced apoptosis in the intestine
por: Xia, Pengpeng, et al.
Publicado: (2021)

N‐Acylethanolamine acid amidase (NAAA) is dysregulated in colorectal cancer patients and its inhibition reduces experimental cancer growth
por: Romano, Barbara, et al.
Publicado: (2021)

Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability
por: Zhou, Bo, et al.
Publicado: (2021)

CRISPR/Cas9-Targeted Mutagenesis of BnaFAE1 Genes Confers Low-Erucic Acid in Brassica napus
por: Liu, Yunhao, et al.
Publicado: (2022)

Efficacy and mechanism of Jiedu Tongluo Tiaogan Formula in treating type 2 diabetes mellitus combined with non-alcoholic fatty liver disease: Study protocol for a parallel-armed, randomized controlled trial
por: Xu, Jinghan, et al.
Publicado: (2022)

Acyl ethanolamides in Diabetes and Diabetic Nephropathy: Novel targets from untargeted plasma metabolomic profiles of South Asian Indian men
por: Devi, Sarita, et al.
Publicado: (2019)

Mendelian Randomization Rules Out Causation Between Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease
por: Chen, Lanlan, et al.
Publicado: (2022)

Pharmacological Blockade of Adenosine A(2A) but Not A(1) Receptors Enhances Goal-Directed Valuation in Satiety-Based Instrumental Behavior
por: Li, Yan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_72fibeb0uotlp97jukvt845n59