Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction

Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, offers renoprotection in diabetes. However, potential for use in nondiabetic kidney disease remains unknown. Herein, we assessed whether dapagliflozin alleviates renal fibrosis by interfering with necroinflammation in a rat model of unilater...

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Detalles Bibliográficos
Autores principales: Xuan, Mei Ying, Piao, Shang Guo, Ding, Jun, Nan, Qi Yan, Piao, Mei Hua, Jiang, Yu Ji, Zheng, Hai Lan, Jin, Ji Zhe, Li, Can
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777292/
https://www.ncbi.nlm.nih.gov/pubmed/35069210
http://dx.doi.org/10.3389/fphar.2021.798381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777292/
https://www.ncbi.nlm.nih.gov/pubmed/35069210
http://dx.doi.org/10.3389/fphar.2021.798381

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