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Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction

Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, offers renoprotection in diabetes. However, potential for use in nondiabetic kidney disease remains unknown. Herein, we assessed whether dapagliflozin alleviates renal fibrosis by interfering with necroinflammation in a rat model of unilater...

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Detalles Bibliográficos
Autores principales:	Xuan, Mei Ying, Piao, Shang Guo, Ding, Jun, Nan, Qi Yan, Piao, Mei Hua, Jiang, Yu Ji, Zheng, Hai Lan, Jin, Ji Zhe, Li, Can
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777292/ https://www.ncbi.nlm.nih.gov/pubmed/35069210 http://dx.doi.org/10.3389/fphar.2021.798381

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