Improving the Estimation of Subgroup Effects for Clinical Trial Participants with Multimorbidity by Incorporating Drug Class-Level Information in Bayesian Hierarchical Models: A Simulation Study

BACKGROUND: There is limited guidance for using common drug therapies in the context of multimorbidity. In part, this is because their effectiveness for patients with specific comorbidities cannot easily be established using subgroup analyses in clinical trials. Here, we use simulations to explore t...

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Detalles Bibliográficos
Autores principales: Hannigan, Laurie J., Phillippo, David M., Hanlon, Peter, Moss, Laura, Butterly, Elaine W., Hawkins, Neil, Dias, Sofia, Welton, Nicky J., McAllister, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777306/
https://www.ncbi.nlm.nih.gov/pubmed/34407672
http://dx.doi.org/10.1177/0272989X211029556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777306/
https://www.ncbi.nlm.nih.gov/pubmed/34407672
http://dx.doi.org/10.1177/0272989X211029556

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