Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels

Lipids modulate the function of many ion channels, possibly through direct lipid-protein interactions. The recent outpouring of ion channel structures by cryo-EM has revealed many lipid binding sites. Whether these sites mediate lipid modulation of ion channel function is not firmly established in m...

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Detalles Bibliográficos
Autores principales: Cheng, Wayland W. L., Arcario, Mark J., Petroff, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777383/
https://www.ncbi.nlm.nih.gov/pubmed/35069257
http://dx.doi.org/10.3389/fphys.2021.798102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777383/
https://www.ncbi.nlm.nih.gov/pubmed/35069257
http://dx.doi.org/10.3389/fphys.2021.798102

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