Cargando…

The Compound (E)-2-Cyano-N,3-diphenylacrylamide (JMPR-01): A Potential Drug for Treatment of Inflammatory Diseases

The compound (E)-2-cyano-N,3-diphenylacrylamide (JMPR-01) was structurally developed using bioisosteric modifications of a hybrid prototype as formed from fragments of indomethacin and paracetamol. Initially, in vitro assays were performed to determine cell viability (in macrophage cultures), and it...

Descripción completa

Detalles Bibliográficos
Autores principales:	da Silva, Pablo Rayff, do Espírito Santo, Renan Fernandes, Melo, Camila de Oliveira, Pachú Cavalcante, Fábio Emanuel, Costa, Thássia Borges, Barbosa, Yasmim Vilarim, e Silva, Yvnni M. S. de Medeiros, de Sousa, Natália Ferreira, Villarreal, Cristiane Flora, de Moura, Ricardo Olímpio, dos Santos, Vanda Lucia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777680/ https://www.ncbi.nlm.nih.gov/pubmed/35057082 http://dx.doi.org/10.3390/pharmaceutics14010188

Ejemplares similares

Anti-Inflammatory Activity of N′-(3-(1H-indol-3-yl)benzylidene)-2-cyanoacetohydrazide Derivative via sGC-NO/Cytokine Pathway
por: da Silva, Pablo Rayff, et al.
Publicado: (2023)

(E)-2-Cyano-3-(1H-Indol-3-yl)-N-Phenylacrylamide, a Hybrid Compound Derived from Indomethacin and Paracetamol: Design, Synthesis and Evaluation of the Anti-Inflammatory Potential
por: Silva, Pablo, et al.
Publicado: (2020)

5-O-methylcneorumchromone K Exerts Antinociceptive Effects in Mice via Interaction with GABAA Receptors
por: Opretzka, Luiza Carolina França, et al.
Publicado: (2021)

Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic Peripheral Neuropathy
por: Oliveira, Anna Lethicia L., et al.
Publicado: (2021)

Unveiling Targets for Treating Postoperative Pain: The Role of the TNF-α/p38 MAPK/NF-κB/Nav1.8 and Nav1.9 Pathways in the Mouse Model of Incisional Pain
por: de Lima, Flávia Oliveira, et al.
Publicado: (2022)

Redetermination of 4-cyanopyridine N-oxide
por: Moreno-Fuquen, Rodolfo, et al.
Publicado: (2012)

4-Cyanobenzaldehyde thiosemicarbazone
por: Wu, De-Hong, et al.
Publicado: (2008)

Cyanomethanaminium perchlorate
por: Quan, Jing
Publicado: (2012)

N,N′-Bis[(E)-4-cyanobenzylidene]urea
por: Wu, De-Hong, et al.
Publicado: (2009)

Pharmacological Properties of Riparin IV in Models of Pain and Inflammation
por: Nascimento, Olívia Azevêdo, et al.
Publicado: (2016)

Branched-chain C-cyano pyranonucleosides: Synthesis of 3′-C-cyano & 3′-C-cyano-3′-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents
por: Kiritsis, Christos, et al.
Publicado: (2011)

Antinociceptive compounds and LC-DAD-ESIMS(n) profile from Dictyoloma vandellianum leaves
por: Abreu, Lucas Silva, et al.
Publicado: (2019)

4-Cyanoanilinium perchlorate
por: Dai, Jing
Publicado: (2008)

4-Cyanopyridinium chloride
por: Zheng, Wen-Ni
Publicado: (2012)

4-Cyanopyridinium bromide
por: Zheng, Wen-Ni
Publicado: (2012)

4-Cyanopyridinium nitrate
por: Zheng, Wen-Ni
Publicado: (2012)

2-Cyanoanilinium perchlorate
por: Cui, Li-Jing, et al.
Publicado: (2010)

3-Cyanoanilinium chloride
por: Wen, Xiao-Chun
Publicado: (2008)

2-Cyanoanilinium nitrate
por: Cui, Li-Jing, et al.
Publicado: (2008)

3-Cyanoanilinium nitrate
por: Wang, Bo
Publicado: (2009)

3-Cyanoanilinium bromide
por: Wang, Bo
Publicado: (2009)

2-Cyanoanilinium bromide
por: Zhang, Li
Publicado: (2009)

4-Cyanoanilinium iodide
por: Mague, Joel T., et al.
Publicado: (2012)

2-Cyanoanilinium iodide
por: Vumbaco, David J., et al.
Publicado: (2013)

4-Cyanoanilinium bromide
por: Vumbaco, David J., et al.
Publicado: (2012)

The anti-inflammatory and immunomodulatory potential of braylin: Pharmacological properties and mechanisms by in silico, in vitro and in vivo approaches
por: Espírito-Santo, Renan Fernandes, et al.
Publicado: (2017)

The importance of applying the statement of assent to children and adolescents: a qualitative study**
por: da Silva Varejão, Cristiane, et al.
Publicado: (2022)

Blood Pressure Treatment Adherence and Control after Participation in the ReHOT
por: de Jesus, Nathália Silva, et al.
Publicado: (2016)

Cyano-borrowing reaction: nickel-catalyzed direct conversion of cyanohydrins and aldehydes/ketones to β-cyano ketone
por: Li, Zhao-Feng, et al.
Publicado: (2019)

2-Cyano-2-methylpropanamide
por: Xu, Jia-Ying, et al.
Publicado: (2012)

N-(Cyanomethyl)benzamide
por: Aouine, Younas, et al.
Publicado: (2010)

2-Cyanoanilinium dihydrogen phosphate
por: Zhang, Li
Publicado: (2009)

3-Cyanoanilinium iodide monohydrate
por: Dai, Jing, et al.
Publicado: (2010)

2-Bromobenzaldehyde cyanohydrin
por: Betz, Richard, et al.
Publicado: (2007)

4-Cyanopyridinium hydrogen sulfate
por: Wang, Ying-Chun
Publicado: (2012)

(4-Cyanophenolato)(subphthalocyaninato)boron
por: Paton, Andrew S., et al.
Publicado: (2011)

3-Cyano-N-methylpyridinium perchlorate
por: McCormick, Cameron A., et al.
Publicado: (2014)

Versatility of the Cyano Group in Intermolecular Interactions
por: Scheiner, Steve
Publicado: (2020)

Evaluation of Biological Activity of Polygala Boliviensis in Experimental Models
por: Carneiro da Rocha, José Luiz, et al.
Publicado: (2019)

A Highly Troglomorphic New Genus of Sminthuridae (Collembola, Symphypleona) from the Brazilian Semiarid Region †
por: de Souza, Paolla Gabryelle Cavalcante, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_stf9goaq63q54l1l7quocu105u