New Analogs of Polyamine Toxins from Spiders and Wasps: Liquid Phase Fragment Synthesis and Evaluation of Antiproliferative Activity

Polyamine toxins (PATs) are conjugates of polyamines (PAs) with lipophilic carboxylic acids, which have been recently shown to present antiproliferative activity. Ten analogs of the spider PATs Agel 416, HO-416b, and JSTX-3 and the wasp PAT PhTX-433 were synthesized with changes in the lipophilic he...

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Detalles Bibliográficos
Autores principales: Vassileiou, Christos, Kalantzi, Stefania, Vachlioti, Eleanna, Athanassopoulos, Constantinos M., Koutsakis, Christos, Piperigkou, Zoi, Karamanos, Nikos, Stivarou, Theodora, Lymberi, Peggy, Avgoustakis, Konstantinos, Papaioannou, Dionissios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777946/
https://www.ncbi.nlm.nih.gov/pubmed/35056762
http://dx.doi.org/10.3390/molecules27020447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777946/
https://www.ncbi.nlm.nih.gov/pubmed/35056762
http://dx.doi.org/10.3390/molecules27020447

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