Cargando…

New Analogs of Polyamine Toxins from Spiders and Wasps: Liquid Phase Fragment Synthesis and Evaluation of Antiproliferative Activity

Polyamine toxins (PATs) are conjugates of polyamines (PAs) with lipophilic carboxylic acids, which have been recently shown to present antiproliferative activity. Ten analogs of the spider PATs Agel 416, HO-416b, and JSTX-3 and the wasp PAT PhTX-433 were synthesized with changes in the lipophilic he...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vassileiou, Christos, Kalantzi, Stefania, Vachlioti, Eleanna, Athanassopoulos, Constantinos M., Koutsakis, Christos, Piperigkou, Zoi, Karamanos, Nikos, Stivarou, Theodora, Lymberi, Peggy, Avgoustakis, Konstantinos, Papaioannou, Dionissios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777946/ https://www.ncbi.nlm.nih.gov/pubmed/35056762 http://dx.doi.org/10.3390/molecules27020447

Ejemplares similares

Key Matrix Remodeling Enzymes: Functions and Targeting in Cancer
por: Piperigkou, Zoi, et al.
Publicado: (2021)

Studies towards the Synthesis of Novel 3-Aminopropoxy-Substituted Dioxins Suitable for the Development of Aptamers for Photonic Biosensor Applications
por: Kalantzi, Stefania, et al.
Publicado: (2021)

Effect of polyamines and synthetic polyamine-analogues on the expression of antizyme (AtoC) and its regulatory genes
por: Filippou, Panagiota S, et al.
Publicado: (2007)

Matrix Effectors and Cancer
por: Piperigkou, Zoi, et al.
Publicado: (2021)

Altered Adipokine Expression in Tumor Microenvironment Promotes Development of Triple Negative Breast Cancer
por: Papakonstantinou, Efthymia, et al.
Publicado: (2022)

Trends in extracellular matrix biology
por: Kyriakopoulou, Konstantina, et al.
Publicado: (2022)

Sulfated Hyaluronan Modulates the Functional Properties and Matrix Effectors Expression of Breast Cancer Cells with Different Estrogen Receptor Status
por: Koutsakis, Christos, et al.
Publicado: (2021)

Extracellular Matrix-Mediated Breast Cancer Cells Morphological Alterations, Invasiveness, and Microvesicles/Exosomes Release
por: Franchi, Marco, et al.
Publicado: (2020)

miR-200b restrains EMT and aggressiveness and regulates matrix composition depending on ER status and signaling in mammary cancer
por: Piperigkou, Zoi, et al.
Publicado: (2020)

Conjugation with polyamines enhances the antibacterial and anticancer activity of chloramphenicol
por: Kostopoulou, Ourania N., et al.
Publicado: (2014)

Enhancement of mesenchymal stem cells’ chondrogenic potential by type II collagen-based bioscaffolds
por: Piperigkou, Zoi, et al.
Publicado: (2023)

pH-Sensitive Gold Nanorods for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Delivery and DNA-Binding Studies
por: Zygouri, Eleni, et al.
Publicado: (2023)

Collagen Fiber Array of Peritumoral Stroma Influences Epithelial-to-Mesenchymal Transition and Invasive Potential of Mammary Cancer Cells
por: Franchi, Marco, et al.
Publicado: (2019)

Long filopodia and tunneling nanotubes define new phenotypes of breast cancer cells in 3D cultures
por: Franchi, Marco, et al.
Publicado: (2020)

(2E,4E,6E)-3-Methyl-7-(pyren-1-yl)octa-2,4,6-trienoic acid
por: Bariamis, Stavros E., et al.
Publicado: (2009)

Levels of Circulating IgM and IgY Natural Antibodies in Broiler Chicks: Association with Genotype and Farming Systems
por: Sarrigeorgiou, Ioannis, et al.
Publicado: (2023)

New records of spider wasps (Hymenoptera, Pompilidae) from Colombia
por: Castro-Huertas, Valentina, et al.
Publicado: (2014)

Co-occurrence of ecologically equivalent cryptic species of spider wasps
por: Kurushima, Hiroaki, et al.
Publicado: (2016)

ESR2 Drives Mesenchymal-to-Epithelial Transition in Triple-Negative Breast Cancer and Tumorigenesis In Vivo
por: Piperigkou, Zoi, et al.
Publicado: (2022)

The Role of Exosomes in Epithelial–to-Mesenchymal Transition and Cell Functional Properties in Head and Neck Cancer
por: Mastronikolis, Nicholas S., et al.
Publicado: (2023)

How Necessary is the Vasculature in the Life of Neural Stem and Progenitor Cells? Evidence from Evolution, Development and the Adult Nervous System
por: Koutsakis, Christos, et al.
Publicado: (2016)

A Parasitoid Wasp Induces Overwintering Behaviour in Its Spider Host
por: Korenko, Stanislav, et al.
Publicado: (2011)

More new records of spider wasps from Colombia (Hymenoptera, Pompilidae)
por: Waichert, Cecilia, et al.
Publicado: (2017)

A Short Review of the Venoms and Toxins of Spider Wasps (Hymenoptera: Pompilidae)
por: Dashevsky, Daniel, et al.
Publicado: (2021)

ΕGFR/ERβ-Mediated Cell Morphology and Invasion Capacity Are Associated with Matrix Culture Substrates in Breast Cancer
por: Kyriakopoulou, Konstantina, et al.
Publicado: (2020)

Epigenetic Alterations in Triple-Negative Breast Cancer—The Critical Role of Extracellular Matrix
por: Zolota, Vasiliki, et al.
Publicado: (2021)

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells
por: Wilson, David, et al.
Publicado: (2017)

Novel Tripodal Polyamine Tris-Pyrene: DNA/RNA Binding and Photodynamic Antiproliferative Activity
por: Jurković, Marta, et al.
Publicado: (2023)

From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs
por: Nordio, Giulia, et al.
Publicado: (2023)

A Unique Nest-Protection Strategy in a New Species of Spider Wasp
por: Staab, Michael, et al.
Publicado: (2014)

Müllerian Mimicry as a Result of Codivergence between Velvet Ants and Spider Wasps
por: Rodriguez, Juanita, et al.
Publicado: (2014)

Extracellular Molecules Involved in Cancer Cell Invasion
por: Stivarou, Theodora, et al.
Publicado: (2015)

Differences in Performance of ASD and ADHD Subjects Facing Cognitive Loads in an Innovative Reasoning Experiment
por: Papaioannou, Anastasia, et al.
Publicado: (2021)

Effects of Habitat Fragmentation on Abundance, Larval Food and Parasitism of a Spider-Hunting Wasp
por: Coudrain, Valérie, et al.
Publicado: (2013)

Proximate mechanism of behavioral manipulation of an orb-weaver spider host by a parasitoid wasp
por: Kloss, Thiago Gechel, et al.
Publicado: (2017)

Specialists and generalists coexist within a population of spider-hunting mud dauber wasps
por: Powell, Erin C., et al.
Publicado: (2017)

Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current Solutions
por: Dinos, George P., et al.
Publicado: (2016)

Synthesis and Antiproliferative Activity of Novel Dehydroabietic Acid-Chalcone Hybrids
por: Grigoropoulou, Sophia, et al.
Publicado: (2022)

Complexity analysis of the brain activity in Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) due to cognitive loads/demands induced by Aristotle's type of syllogism/reasoning. A Power Spectral Density and multiscale entropy (MSE) analysis
por: Papaioannou, Anastasia G., et al.
Publicado: (2021)

Bioinspired Syntheses of Dimeric Hydroxycinnamic Acids (Lignans) and Hybrids, Using Phenol Oxidative Coupling as Key Reaction, and Medicinal Significance Thereof †
por: Magoulas, George E., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_q3gs0mmkd0shek35u537i5he8n