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Approach for the Design of Covalent Protein Kinase Inhibitors via Focused Deep Generative Modeling
Deep machine learning is expanding the conceptual framework and capacity of computational compound design, enabling new applications through generative modeling. We have explored the systematic design of covalent protein kinase inhibitors by learning from kinome-relevant chemical space, followed by...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778003/ https://www.ncbi.nlm.nih.gov/pubmed/35056884 http://dx.doi.org/10.3390/molecules27020570 |