Synthesis and Biological Activity of 3-(Heteroaryl)quinolin-2(1H)-ones Bis-Heterocycles as Potential Inhibitors of the Protein Folding Machinery Hsp90

In the context of our SAR study concerning 6BrCaQ analogues as C-terminal Hsp90 inhibitors, we designed and synthesized a novel series of 3-(heteroaryl)quinolin-2(1H), of types 3, 4, and 5, as a novel class of analogues. A Pd-catalyzed Liebeskind–Srogl cross-coupling was developed as a convenient ap...

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Detalles Bibliográficos
Autores principales: Larghi, Enrique L., Bruneau, Alexandre, Sauvage, Félix, Alami, Mouad, Vergnaud-Gauduchon, Juliette, Messaoudi, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778022/
https://www.ncbi.nlm.nih.gov/pubmed/35056725
http://dx.doi.org/10.3390/molecules27020412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778022/
https://www.ncbi.nlm.nih.gov/pubmed/35056725
http://dx.doi.org/10.3390/molecules27020412

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