Synthesis and Characterization of a New Norfloxacin/Resorcinol Cocrystal with Enhanced Solubility and Dissolution Profile

A new cocrystal of Norfloxacin, a poorly soluble fluoroquinolone antibiotic, has been synthetized by a solvent-mediated transformation experiment in toluene, using resorcinol as a coformer. The new cocrystal exists in both anhydrous and monohydrate forms with the same (1:1) Norfloxacin/resorcinol st...

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Detalles Bibliográficos
Autores principales: Fael, Hanan, Barbas, Rafael, Prohens, Rafel, Ràfols, Clara, Fuguet, Elisabet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778133/
https://www.ncbi.nlm.nih.gov/pubmed/35056945
http://dx.doi.org/10.3390/pharmaceutics14010049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778133/
https://www.ncbi.nlm.nih.gov/pubmed/35056945
http://dx.doi.org/10.3390/pharmaceutics14010049

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