Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model

The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in v...

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Detalles Bibliográficos
Autores principales: Schütt, Michael, O’Farrell, Connor, Stamatopoulos, Konstantinos, Hoad, Caroline L., Marciani, Luca, Sulaiman, Sarah, Simmons, Mark J. H., Batchelor, Hannah K., Alexiadis, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778200/
https://www.ncbi.nlm.nih.gov/pubmed/35057077
http://dx.doi.org/10.3390/pharmaceutics14010184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778200/
https://www.ncbi.nlm.nih.gov/pubmed/35057077
http://dx.doi.org/10.3390/pharmaceutics14010184

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