Cargando…

Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives

Imidazolidine and thiazolidine-based isatin derivatives (IST-01–04) were synthesized, characterized, and tested for their interactions with ds-DNA. Theoretical and experimental findings showed good compatibility and indicated compound–DNA binding by mixed mode of interactions. The evaluated binding...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arshad, Nasima, Mir, Muhammad Ismail, Perveen, Fouzia, Javed, Aneela, Javaid, Memona, Saeed, Aamer, Channar, Pervaiz Ali, Farooqi, Shahid Iqbal, Alkahtani, Saad, Anwar, Jamshed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778244/ https://www.ncbi.nlm.nih.gov/pubmed/35056668 http://dx.doi.org/10.3390/molecules27020354

Ejemplares similares

Investigation of Newly Synthesized Bis-Acyl-Thiourea Derivatives of 4-Nitrobenzene-1,2-Diamine for Their DNA Binding, Urease Inhibition, and Anti-Brain-Tumor Activities
por: Arshad, Nasima, et al.
Publicado: (2023)

Identification of two novel thiazolidin-2-imines as tyrosinase inhibitors: synthesis, crystal structure, molecular docking and DFT studies
por: Shehzadi, Syeda Aaliya, et al.
Publicado: (2022)

Synthesis, X-ray crystal structure elucidation and Hirshfeld surface analysis of N-((4-(1H-benzo[d]imidazole-2-yl)phenyl)carbamothioyl)benzamide: investigations for elastase inhibition, antioxidant and DNA binding potentials for biological applications
por: Arshad, Nasima, et al.
Publicado: (2020)

Structure and surface analyses of a newly synthesized acyl thiourea derivative along with its in silico and in vitro investigations for RNR, DNA binding, urease inhibition and radical scavenging activities
por: Khalid, Aqsa, et al.
Publicado: (2022)

Appraisal of novel azomethine–thioxoimidazolidinone conjugates as ecto-5′-nucleotidase inhibitors: synthesis and molecular docking studies
por: Channar, Pervaiz Ali, et al.
Publicado: (2022)

Synthesis, Biological Evaluation, and Molecular Dynamics of Carbothioamides Derivatives as Carbonic Anhydrase II and 15-Lipoxygenase Inhibitors
por: Channar, Pervaiz Ali, et al.
Publicado: (2022)

Targeting PPAR-γ to design and synthesize antidiabetic thiazolidines
por: Sawant, Ramesh L., et al.
Publicado: (2018)

Electrochemical, spectroscopic and theoretical monitoring of anthracyclines’ interactions with DNA and ascorbic acid by adopting two routes: Cancer cell line studies
por: Perveen, Fouzia, et al.
Publicado: (2018)

Bis-Schiff bases of 2,2′-dibromobenzidine as efficient corrosion inhibitors for mild steel in acidic medium
por: Arshad, Ifzan, et al.
Publicado: (2020)

Investigating effect of mutation on structure and function of G6PD enzyme: a comparative molecular dynamics simulation study
por: Rani, Sadaf, et al.
Publicado: (2022)

Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors
por: Hassan, Sidra, et al.
Publicado: (2018)

N-Benzylisatin
por: Schutte, M., et al.
Publicado: (2012)

1-Phenylisatin
por: Shukla, Deepak, et al.
Publicado: (2011)

Synthesis and Preliminary Antimicrobial Analysis of Isatin–Ferrocene and Isatin–Ferrocenyl Chalcone Conjugates
por: Singh, Amandeep, et al.
Publicado: (2018)

Synthesis of New Imidazolidin-2,4-dione and 2-Thioxo-imidazolidin-4-ones via C-Phenylglycine Derivatives
por: de Sousa Luis, José Alixandre, et al.
Publicado: (2009)

Computational and theoretical chemistry of newly synthesized and characterized 2,2(’)-(5,5(’)-(1,4-phenylene)bis(1H-tetrazole-5,1-diyl))bis-N-acetamides
por: Ejaz, Syeda Abida, et al.
Publicado: (2023)

5-(4-Fluorophenyl)-5-methylimidazolidine-2,4-dione
por: Kashif, M. Kaleem, et al.
Publicado: (2008)

1,3-Dibenzylimidazolidine-2-thione
por: Mietlarek-Kropidłowska, Anna, et al.
Publicado: (2012)

Microbiological Evaluation of 4-substituted-imidazolidine Derivatives
por: Khan, M. S. Y., et al.
Publicado: (2012)

Fetomaternal Outcome Among the Pregnant Women Subject to the Induction of Labor
por: Kazi, Sarah, et al.
Publicado: (2021)

Azide–Alkyne Cycloaddition En Route to 1H-1,2,3-Triazole-Tethered Isatin–Ferrocene, Ferrocenylmethoxy–Isatin, and Isatin–Ferrocenylchalcone Conjugates: Synthesis and Antiproliferative Evaluation
por: Singh, Amandeep, et al.
Publicado: (2018)

5-(Trifluoromethoxy)isatin
por: Schutte, M., et al.
Publicado: (2012)

Experimental spectral characterization, Hirshfeld surface analysis, DFT/TD-DFT calculations and docking studies of (2Z,5Z)-5-(4-nitrobenzylidene)-3-N(2-methoxyphenyl)-2-N’(2-methoxyphenylimino) thiazolidin-4-one
por: Djafri, Ahmed, et al.
Publicado: (2020)

5-Isopropylimidazolidine-2,4-dione monohydrate
por: Abdel-Aziz, Alaa A.-M., et al.
Publicado: (2012)

meso-4,5-Diphenylimidazolidin-2-one
por: Galas, Henry, et al.
Publicado: (2009)

1-Methyl-3-phenylimidazolidine-2-thione
por: Nor, Nabihah Al Muna Mohd, et al.
Publicado: (2014)

Imidazolidine Hydride Donors in Palladium-Catalyzed Alkyne Hydroarylation
por: Tun, Soe L., et al.
Publicado: (2022)

1-(4-Methoxyphenylsulfonyl)-5-methyl-5-phenylimidazolidine-2,4-dione
por: Hussain, Abid, et al.
Publicado: (2009)

Anticancer Effects with Molecular Docking Confirmation of Newly Synthesized Isatin Sulfonamide Molecular Hybrid Derivatives against Hepatic Cancer Cell Lines
por: Eldeeb, Mahmoud, et al.
Publicado: (2022)

Sulfonamide-Linked Ciprofloxacin, Sulfadiazine and Amantadine Derivatives as a Novel Class of Inhibitors of Jack Bean Urease; Synthesis, Kinetic Mechanism and Molecular Docking
por: Channar, Pervaiz Ali, et al.
Publicado: (2017)

Transition metal complexes of an isatinic quinolyl hydrazone
por: Seleem, Hussein S
Publicado: (2011)

A pharmacokinetic study of Isatin in Beagles' bodies
por: REN, AILING, et al.
Publicado: (2016)

Copper-catalyzed reaction of aziridine for the synthesis of substituted imidazolidine and imidazolidinone
por: Hashimoto, Kota, et al.
Publicado: (2023)

Exploring Amantadine Derivatives as Urease Inhibitors: Molecular Docking and Structure–Activity Relationship (SAR) Studies
por: Ahmed, Atteeque, et al.
Publicado: (2021)

Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19
por: Ilyas, Mubashar, et al.
Publicado: (2022)

1-(4-Chlorophenylsulfonyl)-5-(4-fluorophenyl)-5-methylimidazolidine-2,4-dione
por: Hussain, Abid, et al.
Publicado: (2009)

1-Acetyl-4-(phenylsulfanyl)imidazolidin-2-one
por: Abdel-Aziz, Alaa A.-M., et al.
Publicado: (2012)

1,3-Dicyclohexylimidazolidine-2,4,5-trione
por: Talhi, Oualid, et al.
Publicado: (2011)

2,2′-[Imidazolidine-1,3-diylbis(methylene)]diphenol
por: Rivera, Augusto, et al.
Publicado: (2011)

1-Acetyl-5-isobutyl-2-sulfanylideneimidazolidin-4-one
por: Li, Kaozhen, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_uibrbfofpef695e3h1d1m99ato