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Relaxed Substrate Specificity in Qβ Replicase through Long-Term In Vitro Evolution

A change from RNA- to DNA-based genetic systems is hypothesized as a major transition in the evolution of early life forms. One of the possible requirements for this transition is a change in the substrate specificity of the replication enzyme. It is largely unknown how such changes would have occur...

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Detalles Bibliográficos
Autores principales: Yukawa, Kohtoh, Mizuuchi, Ryo, Ichihashi, Norikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778257/
https://www.ncbi.nlm.nih.gov/pubmed/35054425
http://dx.doi.org/10.3390/life12010032