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Novel Disulfiram Derivatives as ALDH1a1-Selective Inhibitors
Aldehyde dehydrogenase-1a1 (ALDH1a1), the enzyme responsible for the oxidation of retinal into retinoic acid, represents a key therapeutic target for the treatment of debilitating disorders such as cancer, obesity, and inflammation. Drugs that can inhibit ALDH1a1 include disulfiram, an FDA-approved...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778300/ https://www.ncbi.nlm.nih.gov/pubmed/35056791 http://dx.doi.org/10.3390/molecules27020480 |