Cargando…
The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease
The type of diet not only affects the composition of the oral microflora but is also one of the more critical factors associated with an increased risk of Parkinson’s disease, PD. This study compared diet preferences and oral microbiota profiles in patients with PD vs. healthy controls. This study c...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778357/ https://www.ncbi.nlm.nih.gov/pubmed/35057536 http://dx.doi.org/10.3390/nu14020355 |
_version_ | 1784637301448507392 |
---|---|
author | Zapała, Barbara Stefura, Tomasz Milewicz, Tomasz Wątor, Julia Piwowar, Monika Wójcik-Pędziwiatr, Magdalena Doręgowska, Magdalena Dudek, Alicja Jania, Zuzanna Rudzińska-Bar, Monika |
author_facet | Zapała, Barbara Stefura, Tomasz Milewicz, Tomasz Wątor, Julia Piwowar, Monika Wójcik-Pędziwiatr, Magdalena Doręgowska, Magdalena Dudek, Alicja Jania, Zuzanna Rudzińska-Bar, Monika |
author_sort | Zapała, Barbara |
collection | PubMed |
description | The type of diet not only affects the composition of the oral microflora but is also one of the more critical factors associated with an increased risk of Parkinson’s disease, PD. This study compared diet preferences and oral microbiota profiles in patients with PD vs. healthy controls. This study compared the oral microbiota composition of 59 patients with PD and 108 healthy controls (without neurodegeneration) using 16S rRNA gene amplicon sequencing. According to results, oral microbiota in patients with PD is different compared from healthy controls. In particular, decreased abundance of Proteobacteria, Pastescibacteria, and Tenercutes was observed. The oral cavity of patients with PD was characterized by the high relative abundance of bacteria from the genera Prevotella, Streptococcus, and Lactobaccillus. There were also differences in food preferences between patients with PD and healthy controls, which revealed significantly higher intake of margarine, fish, red meat, cereals products, avocado, and olives in the patients with PD relative to healthy controls. Strong positive and negative correlations between specific food products and microbial taxa were identified. |
format | Online Article Text |
id | pubmed-8778357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87783572022-01-22 The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease Zapała, Barbara Stefura, Tomasz Milewicz, Tomasz Wątor, Julia Piwowar, Monika Wójcik-Pędziwiatr, Magdalena Doręgowska, Magdalena Dudek, Alicja Jania, Zuzanna Rudzińska-Bar, Monika Nutrients Article The type of diet not only affects the composition of the oral microflora but is also one of the more critical factors associated with an increased risk of Parkinson’s disease, PD. This study compared diet preferences and oral microbiota profiles in patients with PD vs. healthy controls. This study compared the oral microbiota composition of 59 patients with PD and 108 healthy controls (without neurodegeneration) using 16S rRNA gene amplicon sequencing. According to results, oral microbiota in patients with PD is different compared from healthy controls. In particular, decreased abundance of Proteobacteria, Pastescibacteria, and Tenercutes was observed. The oral cavity of patients with PD was characterized by the high relative abundance of bacteria from the genera Prevotella, Streptococcus, and Lactobaccillus. There were also differences in food preferences between patients with PD and healthy controls, which revealed significantly higher intake of margarine, fish, red meat, cereals products, avocado, and olives in the patients with PD relative to healthy controls. Strong positive and negative correlations between specific food products and microbial taxa were identified. MDPI 2022-01-14 /pmc/articles/PMC8778357/ /pubmed/35057536 http://dx.doi.org/10.3390/nu14020355 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zapała, Barbara Stefura, Tomasz Milewicz, Tomasz Wątor, Julia Piwowar, Monika Wójcik-Pędziwiatr, Magdalena Doręgowska, Magdalena Dudek, Alicja Jania, Zuzanna Rudzińska-Bar, Monika The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease |
title | The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease |
title_full | The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease |
title_fullStr | The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease |
title_full_unstemmed | The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease |
title_short | The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease |
title_sort | role of the western diet and oral microbiota in parkinson’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778357/ https://www.ncbi.nlm.nih.gov/pubmed/35057536 http://dx.doi.org/10.3390/nu14020355 |
work_keys_str_mv | AT zapałabarbara theroleofthewesterndietandoralmicrobiotainparkinsonsdisease AT stefuratomasz theroleofthewesterndietandoralmicrobiotainparkinsonsdisease AT milewicztomasz theroleofthewesterndietandoralmicrobiotainparkinsonsdisease AT watorjulia theroleofthewesterndietandoralmicrobiotainparkinsonsdisease AT piwowarmonika theroleofthewesterndietandoralmicrobiotainparkinsonsdisease AT wojcikpedziwiatrmagdalena theroleofthewesterndietandoralmicrobiotainparkinsonsdisease AT doregowskamagdalena theroleofthewesterndietandoralmicrobiotainparkinsonsdisease AT dudekalicja theroleofthewesterndietandoralmicrobiotainparkinsonsdisease AT janiazuzanna theroleofthewesterndietandoralmicrobiotainparkinsonsdisease AT rudzinskabarmonika theroleofthewesterndietandoralmicrobiotainparkinsonsdisease AT zapałabarbara roleofthewesterndietandoralmicrobiotainparkinsonsdisease AT stefuratomasz roleofthewesterndietandoralmicrobiotainparkinsonsdisease AT milewicztomasz roleofthewesterndietandoralmicrobiotainparkinsonsdisease AT watorjulia roleofthewesterndietandoralmicrobiotainparkinsonsdisease AT piwowarmonika roleofthewesterndietandoralmicrobiotainparkinsonsdisease AT wojcikpedziwiatrmagdalena roleofthewesterndietandoralmicrobiotainparkinsonsdisease AT doregowskamagdalena roleofthewesterndietandoralmicrobiotainparkinsonsdisease AT dudekalicja roleofthewesterndietandoralmicrobiotainparkinsonsdisease AT janiazuzanna roleofthewesterndietandoralmicrobiotainparkinsonsdisease AT rudzinskabarmonika roleofthewesterndietandoralmicrobiotainparkinsonsdisease |