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The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease

The type of diet not only affects the composition of the oral microflora but is also one of the more critical factors associated with an increased risk of Parkinson’s disease, PD. This study compared diet preferences and oral microbiota profiles in patients with PD vs. healthy controls. This study c...

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Autores principales: Zapała, Barbara, Stefura, Tomasz, Milewicz, Tomasz, Wątor, Julia, Piwowar, Monika, Wójcik-Pędziwiatr, Magdalena, Doręgowska, Magdalena, Dudek, Alicja, Jania, Zuzanna, Rudzińska-Bar, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778357/
https://www.ncbi.nlm.nih.gov/pubmed/35057536
http://dx.doi.org/10.3390/nu14020355
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author Zapała, Barbara
Stefura, Tomasz
Milewicz, Tomasz
Wątor, Julia
Piwowar, Monika
Wójcik-Pędziwiatr, Magdalena
Doręgowska, Magdalena
Dudek, Alicja
Jania, Zuzanna
Rudzińska-Bar, Monika
author_facet Zapała, Barbara
Stefura, Tomasz
Milewicz, Tomasz
Wątor, Julia
Piwowar, Monika
Wójcik-Pędziwiatr, Magdalena
Doręgowska, Magdalena
Dudek, Alicja
Jania, Zuzanna
Rudzińska-Bar, Monika
author_sort Zapała, Barbara
collection PubMed
description The type of diet not only affects the composition of the oral microflora but is also one of the more critical factors associated with an increased risk of Parkinson’s disease, PD. This study compared diet preferences and oral microbiota profiles in patients with PD vs. healthy controls. This study compared the oral microbiota composition of 59 patients with PD and 108 healthy controls (without neurodegeneration) using 16S rRNA gene amplicon sequencing. According to results, oral microbiota in patients with PD is different compared from healthy controls. In particular, decreased abundance of Proteobacteria, Pastescibacteria, and Tenercutes was observed. The oral cavity of patients with PD was characterized by the high relative abundance of bacteria from the genera Prevotella, Streptococcus, and Lactobaccillus. There were also differences in food preferences between patients with PD and healthy controls, which revealed significantly higher intake of margarine, fish, red meat, cereals products, avocado, and olives in the patients with PD relative to healthy controls. Strong positive and negative correlations between specific food products and microbial taxa were identified.
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spelling pubmed-87783572022-01-22 The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease Zapała, Barbara Stefura, Tomasz Milewicz, Tomasz Wątor, Julia Piwowar, Monika Wójcik-Pędziwiatr, Magdalena Doręgowska, Magdalena Dudek, Alicja Jania, Zuzanna Rudzińska-Bar, Monika Nutrients Article The type of diet not only affects the composition of the oral microflora but is also one of the more critical factors associated with an increased risk of Parkinson’s disease, PD. This study compared diet preferences and oral microbiota profiles in patients with PD vs. healthy controls. This study compared the oral microbiota composition of 59 patients with PD and 108 healthy controls (without neurodegeneration) using 16S rRNA gene amplicon sequencing. According to results, oral microbiota in patients with PD is different compared from healthy controls. In particular, decreased abundance of Proteobacteria, Pastescibacteria, and Tenercutes was observed. The oral cavity of patients with PD was characterized by the high relative abundance of bacteria from the genera Prevotella, Streptococcus, and Lactobaccillus. There were also differences in food preferences between patients with PD and healthy controls, which revealed significantly higher intake of margarine, fish, red meat, cereals products, avocado, and olives in the patients with PD relative to healthy controls. Strong positive and negative correlations between specific food products and microbial taxa were identified. MDPI 2022-01-14 /pmc/articles/PMC8778357/ /pubmed/35057536 http://dx.doi.org/10.3390/nu14020355 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zapała, Barbara
Stefura, Tomasz
Milewicz, Tomasz
Wątor, Julia
Piwowar, Monika
Wójcik-Pędziwiatr, Magdalena
Doręgowska, Magdalena
Dudek, Alicja
Jania, Zuzanna
Rudzińska-Bar, Monika
The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease
title The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease
title_full The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease
title_fullStr The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease
title_full_unstemmed The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease
title_short The Role of the Western Diet and Oral Microbiota in Parkinson’s Disease
title_sort role of the western diet and oral microbiota in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778357/
https://www.ncbi.nlm.nih.gov/pubmed/35057536
http://dx.doi.org/10.3390/nu14020355
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