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Pharmacokinetic Evaluation of a Novel Donepezil-Loaded Dissolving Microneedle Patch in Rats

Research on the development of dissolving microneedles (DMNs) has focused on bolus drug delivery, with little attention on sustained release. Here, we evaluated the sustained release, absorption pattern, and effective drug permeation of a novel donepezil-loaded DMN patch through an in vivo investiga...

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Detalles Bibliográficos
Autores principales: Rehman, Naveed Ur, Song, Chanwoo, Kim, Junhyeong, Noh, Inhwan, Rhee, Yun-Seok, Chung, Hye Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778454/
https://www.ncbi.nlm.nih.gov/pubmed/35056902
http://dx.doi.org/10.3390/pharmaceutics14010005