Impact of TR(34)/L98H, TR(46)/Y121F/T289A and TR(53) Alterations in Azole-Resistant Aspergillus fumigatus on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole

Background: Sterols are the main components of fungal membranes. Inhibiting their biosynthesis is the mode of action of azole antifungal drugs that are widely used to treat fungal disease including aspergillosis. Azole resistance has emerged as a matter of concern but little is known about sterols b...

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Detalles Bibliográficos
Autores principales: Lavergne, Rose-Anne, Albassier, Marjorie, Hardouin, Jean-Benoît, Alvarez-Moreno, Carlos, Pagniez, Fabrice, Morio, Florent, Le Pape, Patrice, Ourliac-Garnier, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778474/
https://www.ncbi.nlm.nih.gov/pubmed/35056552
http://dx.doi.org/10.3390/microorganisms10010104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778474/
https://www.ncbi.nlm.nih.gov/pubmed/35056552
http://dx.doi.org/10.3390/microorganisms10010104

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