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Impact of TR(34)/L98H, TR(46)/Y121F/T289A and TR(53) Alterations in Azole-Resistant Aspergillus fumigatus on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole
Background: Sterols are the main components of fungal membranes. Inhibiting their biosynthesis is the mode of action of azole antifungal drugs that are widely used to treat fungal disease including aspergillosis. Azole resistance has emerged as a matter of concern but little is known about sterols b...
Autores principales: | Lavergne, Rose-Anne, Albassier, Marjorie, Hardouin, Jean-Benoît, Alvarez-Moreno, Carlos, Pagniez, Fabrice, Morio, Florent, Le Pape, Patrice, Ourliac-Garnier, Isabelle |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778474/ https://www.ncbi.nlm.nih.gov/pubmed/35056552 http://dx.doi.org/10.3390/microorganisms10010104 |
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