Modeling SARS-CoV-2 Infection in Mice Using Lentiviral hACE2 Vectors Infers Two Modes of Immune Responses to SARS-CoV-2 Infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a severe global pandemic. Mice models are essential to investigate infection pathology, antiviral drugs, and vaccine development. However, wild-type mice lack the human angiotensin-converting enzyme 2 (hACE2) that mediates SARS-CoV-...

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Detalles Bibliográficos
Autores principales: Katzman, Chaja, Israely, Tomer, Melamed, Sharon, Politi, Boaz, Sittner, Assa, Yahalom-Ronen, Yfat, Weiss, Shay, Abu Rass, Reem, Zamostiano, Rachel, Bacharach, Eran, Ehrlich, Marcelo, Paran, Nir, Nissim, Lior
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778683/
https://www.ncbi.nlm.nih.gov/pubmed/35062215
http://dx.doi.org/10.3390/v14010011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778683/
https://www.ncbi.nlm.nih.gov/pubmed/35062215
http://dx.doi.org/10.3390/v14010011

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