Albumin–Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells

A family of monomodified bovine serum albumin (BSA) linked to methotrexate (MTX) through a variety of spacers was prepared. All analogues were found to be prodrugs having low MTX-inhibitory potencies toward dihydrofolate reductase in a cell-free system. The optimal conjugates regenerated their antip...

Descripción completa

Detalles Bibliográficos
Autores principales: Cooper, Itzik, Schnaider-Beeri, Michal, Fridkin, Mati, Shechter, Yoram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778984/
https://www.ncbi.nlm.nih.gov/pubmed/35056966
http://dx.doi.org/10.3390/pharmaceutics14010071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778984/
https://www.ncbi.nlm.nih.gov/pubmed/35056966
http://dx.doi.org/10.3390/pharmaceutics14010071

Ejemplares similares