The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs

Plasmodium has evolved to regulate the levels and oxidative states of iron protoporphyrin IX (Fe-PPIX). Antimalarial endoperoxides such as 1,2,4-trioxane artemisinin and 1,2,4-trioxolane arterolane undergo a bioreductive activation step mediated by heme (FeII-PPIX) but not by hematin (FeIII-PPIX), l...

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Detalles Bibliográficos
Autores principales: Quadros, Helenita C., Silva, Mariana C. B., Moreira, Diogo R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779033/
https://www.ncbi.nlm.nih.gov/pubmed/35056117
http://dx.doi.org/10.3390/ph15010060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779033/
https://www.ncbi.nlm.nih.gov/pubmed/35056117
http://dx.doi.org/10.3390/ph15010060

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