Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent–Umbrella–Bucket Design

The working definition of health is often the simple absence of diagnosed disease. This common standard is limiting given that changes in functional health status represent early warning signs of impending health declines. Longitudinal assessment of functional health status may foster prevention of...

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Autores principales: Lamb, Joseph J., Stone, Michael, D’Adamo, Christopher R., Volkov, Andrey, Metti, Dina, Aronica, Lucia, Minich, Deanna, Leary, Michelle, Class, Monique, Carullo, Malisa, Ryan, Jennifer J., Larson, Ilona A., Lundquist, Erik, Contractor, Nikhat, Eck, Brent, Ordovas, Jose M., Bland, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779079/
https://www.ncbi.nlm.nih.gov/pubmed/35055430
http://dx.doi.org/10.3390/jpm12010115
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author Lamb, Joseph J.
Stone, Michael
D’Adamo, Christopher R.
Volkov, Andrey
Metti, Dina
Aronica, Lucia
Minich, Deanna
Leary, Michelle
Class, Monique
Carullo, Malisa
Ryan, Jennifer J.
Larson, Ilona A.
Lundquist, Erik
Contractor, Nikhat
Eck, Brent
Ordovas, Jose M.
Bland, Jeffrey S.
author_facet Lamb, Joseph J.
Stone, Michael
D’Adamo, Christopher R.
Volkov, Andrey
Metti, Dina
Aronica, Lucia
Minich, Deanna
Leary, Michelle
Class, Monique
Carullo, Malisa
Ryan, Jennifer J.
Larson, Ilona A.
Lundquist, Erik
Contractor, Nikhat
Eck, Brent
Ordovas, Jose M.
Bland, Jeffrey S.
author_sort Lamb, Joseph J.
collection PubMed
description The working definition of health is often the simple absence of diagnosed disease. This common standard is limiting given that changes in functional health status represent early warning signs of impending health declines. Longitudinal assessment of functional health status may foster prevention of disease occurrence and modify disease progression. The LIFEHOUSE (Lifestyle Intervention and Functional Evaluation-Health Outcomes SurvEy) longitudinal research project explores the impact of personalized lifestyle medicine approaches on functional health determinants. Utilizing an adaptive tent–umbrella–bucket design, the LIFEHOUSE study follows the functional health outcomes of adult participants recruited from a self-insured employee population. Participants were each allocated to the tent of an all-inclusive N-of-one case series. After assessing medical history, nutritional physical exam, baseline functional status (utilizing validated tools to measure metabolic, physical, cognitive, emotional and behavioral functional capacity), serum biomarkers, and genomic and microbiome markers, participants were assigned to applicable umbrellas and buckets. Personalized health programs were developed and implemented using systems biology formalism and functional medicine clinical approaches. The comprehensive database (currently 369 analyzable participants) will yield novel interdisciplinary big-health data and facilitate topological analyses focusing on the interactome among each participant’s genomics, microbiome, diet, lifestyle and environment.
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spelling pubmed-87790792022-01-22 Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent–Umbrella–Bucket Design Lamb, Joseph J. Stone, Michael D’Adamo, Christopher R. Volkov, Andrey Metti, Dina Aronica, Lucia Minich, Deanna Leary, Michelle Class, Monique Carullo, Malisa Ryan, Jennifer J. Larson, Ilona A. Lundquist, Erik Contractor, Nikhat Eck, Brent Ordovas, Jose M. Bland, Jeffrey S. J Pers Med Article The working definition of health is often the simple absence of diagnosed disease. This common standard is limiting given that changes in functional health status represent early warning signs of impending health declines. Longitudinal assessment of functional health status may foster prevention of disease occurrence and modify disease progression. The LIFEHOUSE (Lifestyle Intervention and Functional Evaluation-Health Outcomes SurvEy) longitudinal research project explores the impact of personalized lifestyle medicine approaches on functional health determinants. Utilizing an adaptive tent–umbrella–bucket design, the LIFEHOUSE study follows the functional health outcomes of adult participants recruited from a self-insured employee population. Participants were each allocated to the tent of an all-inclusive N-of-one case series. After assessing medical history, nutritional physical exam, baseline functional status (utilizing validated tools to measure metabolic, physical, cognitive, emotional and behavioral functional capacity), serum biomarkers, and genomic and microbiome markers, participants were assigned to applicable umbrellas and buckets. Personalized health programs were developed and implemented using systems biology formalism and functional medicine clinical approaches. The comprehensive database (currently 369 analyzable participants) will yield novel interdisciplinary big-health data and facilitate topological analyses focusing on the interactome among each participant’s genomics, microbiome, diet, lifestyle and environment. MDPI 2022-01-15 /pmc/articles/PMC8779079/ /pubmed/35055430 http://dx.doi.org/10.3390/jpm12010115 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lamb, Joseph J.
Stone, Michael
D’Adamo, Christopher R.
Volkov, Andrey
Metti, Dina
Aronica, Lucia
Minich, Deanna
Leary, Michelle
Class, Monique
Carullo, Malisa
Ryan, Jennifer J.
Larson, Ilona A.
Lundquist, Erik
Contractor, Nikhat
Eck, Brent
Ordovas, Jose M.
Bland, Jeffrey S.
Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent–Umbrella–Bucket Design
title Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent–Umbrella–Bucket Design
title_full Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent–Umbrella–Bucket Design
title_fullStr Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent–Umbrella–Bucket Design
title_full_unstemmed Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent–Umbrella–Bucket Design
title_short Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent–Umbrella–Bucket Design
title_sort personalized lifestyle intervention and functional evaluation health outcomes survey: presentation of the lifehouse study using n-of-one tent–umbrella–bucket design
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779079/
https://www.ncbi.nlm.nih.gov/pubmed/35055430
http://dx.doi.org/10.3390/jpm12010115
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