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The Role of Fructose as a Cardiovascular Risk Factor: An Update

There is increasing presence of fructose in food and drinks, and some evidence suggests that its higher consumption increases cardiovascular risk, although the mechanisms still remain not fully elucidated. Cardiovascular diseases (CVD) are still responsible for one-third of deaths worldwide, and the...

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Autores principales: Busnatu, Stefan-Sebastian, Salmen, Teodor, Pana, Maria-Alexandra, Rizzo, Manfredi, Stallone, Tiziana, Papanas, Nikolaos, Popovic, Djordje, Tanasescu, Denisa, Serban, Dragos, Stoian, Anca Pantea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779080/
https://www.ncbi.nlm.nih.gov/pubmed/35050189
http://dx.doi.org/10.3390/metabo12010067
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author Busnatu, Stefan-Sebastian
Salmen, Teodor
Pana, Maria-Alexandra
Rizzo, Manfredi
Stallone, Tiziana
Papanas, Nikolaos
Popovic, Djordje
Tanasescu, Denisa
Serban, Dragos
Stoian, Anca Pantea
author_facet Busnatu, Stefan-Sebastian
Salmen, Teodor
Pana, Maria-Alexandra
Rizzo, Manfredi
Stallone, Tiziana
Papanas, Nikolaos
Popovic, Djordje
Tanasescu, Denisa
Serban, Dragos
Stoian, Anca Pantea
author_sort Busnatu, Stefan-Sebastian
collection PubMed
description There is increasing presence of fructose in food and drinks, and some evidence suggests that its higher consumption increases cardiovascular risk, although the mechanisms still remain not fully elucidated. Cardiovascular diseases (CVD) are still responsible for one-third of deaths worldwide, and therefore, their prevention should be assessed and managed comprehensively and not by the evaluation of individual risk factor components. Lifestyle risk factors for CVD include low degree of physical activity, high body mass index, alcohol consumption, smoking, and nutritional factors. Indeed, nutritional risk factors for CVD include unhealthy dietary behaviors, such as high intake of refined foods, unhealthy fats, added sugars, and sodium and a low intake of fruits, vegetables, whole grains, fiber, fish, and nuts. Even though there is no definitive association between CVD incidence and high consumption of total sugar, such as sucrose and fructose, there is, however, evidence that total sugars, added sugars, and fructose are harmfully associated with CVD mortality. Since high fructose intake is associated with elevated plasma triglyceride levels, as well as insulin resistance, diabetes hyperuricemia, and non-alcoholic fatty liver disease, further longitudinal studies should be conducted to fully elucidate the potential association between certain sugars and CVD.
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spelling pubmed-87790802022-01-22 The Role of Fructose as a Cardiovascular Risk Factor: An Update Busnatu, Stefan-Sebastian Salmen, Teodor Pana, Maria-Alexandra Rizzo, Manfredi Stallone, Tiziana Papanas, Nikolaos Popovic, Djordje Tanasescu, Denisa Serban, Dragos Stoian, Anca Pantea Metabolites Perspective There is increasing presence of fructose in food and drinks, and some evidence suggests that its higher consumption increases cardiovascular risk, although the mechanisms still remain not fully elucidated. Cardiovascular diseases (CVD) are still responsible for one-third of deaths worldwide, and therefore, their prevention should be assessed and managed comprehensively and not by the evaluation of individual risk factor components. Lifestyle risk factors for CVD include low degree of physical activity, high body mass index, alcohol consumption, smoking, and nutritional factors. Indeed, nutritional risk factors for CVD include unhealthy dietary behaviors, such as high intake of refined foods, unhealthy fats, added sugars, and sodium and a low intake of fruits, vegetables, whole grains, fiber, fish, and nuts. Even though there is no definitive association between CVD incidence and high consumption of total sugar, such as sucrose and fructose, there is, however, evidence that total sugars, added sugars, and fructose are harmfully associated with CVD mortality. Since high fructose intake is associated with elevated plasma triglyceride levels, as well as insulin resistance, diabetes hyperuricemia, and non-alcoholic fatty liver disease, further longitudinal studies should be conducted to fully elucidate the potential association between certain sugars and CVD. MDPI 2022-01-12 /pmc/articles/PMC8779080/ /pubmed/35050189 http://dx.doi.org/10.3390/metabo12010067 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Busnatu, Stefan-Sebastian
Salmen, Teodor
Pana, Maria-Alexandra
Rizzo, Manfredi
Stallone, Tiziana
Papanas, Nikolaos
Popovic, Djordje
Tanasescu, Denisa
Serban, Dragos
Stoian, Anca Pantea
The Role of Fructose as a Cardiovascular Risk Factor: An Update
title The Role of Fructose as a Cardiovascular Risk Factor: An Update
title_full The Role of Fructose as a Cardiovascular Risk Factor: An Update
title_fullStr The Role of Fructose as a Cardiovascular Risk Factor: An Update
title_full_unstemmed The Role of Fructose as a Cardiovascular Risk Factor: An Update
title_short The Role of Fructose as a Cardiovascular Risk Factor: An Update
title_sort role of fructose as a cardiovascular risk factor: an update
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779080/
https://www.ncbi.nlm.nih.gov/pubmed/35050189
http://dx.doi.org/10.3390/metabo12010067
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