Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin

Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2′-O-methylation of ribosomal RNAs (rRNAs), a modification essential for accurate and efficient prot...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Yun, El-Deeb, Ibrahim M., Masic, Veronika, Hartley-Tassell, Lauren, Maggioni, Andrea, von Itzstein, Mark, Ve, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779173/
https://www.ncbi.nlm.nih.gov/pubmed/35056083
http://dx.doi.org/10.3390/ph15010026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779173/
https://www.ncbi.nlm.nih.gov/pubmed/35056083
http://dx.doi.org/10.3390/ph15010026

Ejemplares similares