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Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin

Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2′-O-methylation of ribosomal RNAs (rRNAs), a modification essential for accurate and efficient prot...

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Detalles Bibliográficos
Autores principales:	Shi, Yun, El-Deeb, Ibrahim M., Masic, Veronika, Hartley-Tassell, Lauren, Maggioni, Andrea, von Itzstein, Mark, Ve, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779173/ https://www.ncbi.nlm.nih.gov/pubmed/35056083 http://dx.doi.org/10.3390/ph15010026

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