Synthesis, In Vitro, In Vivo and In Silico Antidiabetic Bioassays of 4-Nitro(thio)phenoxyisobutyric Acids Acting as Unexpected PPARγ Modulators: An In Combo Study

Four isobutyric acids (two nitro and two acetamido derivatives) were prepared in two steps and characterized using spectral analysis. The mRNA concentrations of PPARγ and GLUT-4 (two proteins documented as key diabetes targets) were increased by 3T3-L1 adipocytes treated with compounds 1–4, but an a...

Descripción completa

Detalles Bibliográficos
Autores principales: Colin-Lozano, Blanca, Torres-Gomez, Héctor, Hidalgo-Figueroa, Sergio, Chávez-Silva, Fabiola, Estrada-Soto, Samuel, Almanza-Pérez, Julio Cesar, Navarrete-Vazquez, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779174/
https://www.ncbi.nlm.nih.gov/pubmed/35056159
http://dx.doi.org/10.3390/ph15010102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779174/
https://www.ncbi.nlm.nih.gov/pubmed/35056159
http://dx.doi.org/10.3390/ph15010102

Ejemplares similares