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Jakinibs of All Trades: Inhibiting Cytokine Signaling in Immune-Mediated Pathologies

Over the last 25 years, inhibition of Janus kinases (JAKs) has been pursued as a modality for treating various immune and inflammatory disorders. While the clinical development of JAK inhibitors (jakinibs) began with the investigation of their use in allogeneic transplantation, their widest successf...

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Detalles Bibliográficos
Autores principales: Alexander, Madison, Luo, Yiming, Raimondi, Giorgio, O’Shea, John J., Gadina, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779366/
https://www.ncbi.nlm.nih.gov/pubmed/35056105
http://dx.doi.org/10.3390/ph15010048