Synthesis of Novel (S)-3-(1-Aminoethyl)-8-pyrimidinyl-2-phenylisoquinolin-1(2H)-ones by Suzuki–Miyaura Coupling and Their Cell Toxicity Activities

A series of (S)-3-(1-aminoethyl)-8-pyrimidinyl-2-phenylisoquinoline-1(2H)-ones 3a–3k was synthesized in 40–98% yield through Suzuki–Miyaura coupling using Pd(PPh(3))(2)Cl(2), Sphos, and K(2)CO(3) in THF/H(2)O mixed solvent. All newly synthesized compounds were evaluated for cell viability (IC(50)) a...

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Detalles Bibliográficos
Autores principales: Choi, Ok Kyoung, Sun, Yong Ho, Lee, Hyemi, Lee, Joon Kwang, Lee, Tae Hoon, Kim, Hakwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779526/
https://www.ncbi.nlm.nih.gov/pubmed/35056121
http://dx.doi.org/10.3390/ph15010064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779526/
https://www.ncbi.nlm.nih.gov/pubmed/35056121
http://dx.doi.org/10.3390/ph15010064

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