Lactic Acid Permeability of Aquaporin-9 Enables Cytoplasmic Lactate Accumulation via an Ion Trap

(1) Background: Human aquaporin-9 (AQP9) conducts several small uncharged metabolites, such as glycerol, urea, and lactic acid. Certain brain tumors were shown to upregulate AQP9 expression, and the putative increase in lactic acid permeability was assigned to severity. (2) Methods: We expressed AQP...

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Detalles Bibliográficos
Autores principales: Geistlinger, Katharina, Schmidt, Jana D. R., Beitz, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779662/
https://www.ncbi.nlm.nih.gov/pubmed/35054513
http://dx.doi.org/10.3390/life12010120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779662/
https://www.ncbi.nlm.nih.gov/pubmed/35054513
http://dx.doi.org/10.3390/life12010120

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