An Adaptive Biosystems Engineering Approach towards Modeling the Soluble-to-Insoluble Phase Transition of Clofazimine

Clofazimine (CFZ) is a weakly basic, small-molecule antibiotic used for the treatment of mycobacterial infections including leprosy and multidrug-resistant tuberculosis. Upon prolonged oral administration, CFZ precipitates and accumulates within macrophages throughout the host. To model the pharmaco...

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Detalles Bibliográficos
Autores principales: Willmer, Andrew R., Dunne, Steven, Swanson, Rosemary, Almeida, Deepak, Ammerman, Nicole C., Stringer, Kathleen A., Capparelli, Edmund V., Rosania, Gus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779763/
https://www.ncbi.nlm.nih.gov/pubmed/35056913
http://dx.doi.org/10.3390/pharmaceutics14010017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779763/
https://www.ncbi.nlm.nih.gov/pubmed/35056913
http://dx.doi.org/10.3390/pharmaceutics14010017

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